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QURE vs SPY

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uniQure N.V. (QURE) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: QURE -29.21%, SPY +86.64%. Regime QURE CRISIS · SPY BULL. As of Oct 13, 2026. Research only.

QUREuniQure N.V.SPYState Street SPDR S&P 500 ETF Trust
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Total return · dividends and splits
-74%-37%0%+37%+74%+111%10-15’2108-15’2206-13’2304-11’2402-10’2512-0810-07’26QURE -29.2%SPY +86.6%lopjlb.com
QURE
SPY
SYMBOLPRICECHANGE5Y %PREV CLOSEDIRREGIME
QUREuniQure N.V.$21.28—-2.56%-29.21%—🔒🔒
SPYState Street SPDR S&P 500 ETF Trust$778.01—-0.01%+86.64%—🔒🔒
DRAWDOWN · THIS RANGE
SYMBOLCURRENTPEAKWORSTTROUGH
QURE-69.85%2025-10-29-89.50%2024-07-08
SPY-0.14%2026-10-06-24.49%2022-10-12
PERIODS · 5Y BOOK
SYMBOL1Y2Y3Y5Y
QURE----
SPY----
ANNUAL · 5Y BOOK
YEARQURESPY
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Compare FAQ

What does the QURE vs SPY overlay show?
LOPJLB overlays QURE vs SPY as total return (dividends and splits) from the first adjusted close in the selected 5Y window. Each path starts at 0% so you can read relative holding performance, not raw tape price.
Is this holding return or tape close?
Holding return. The series uses split- and dividend-adjusted close (Yahoo-style backward adjustment) when dividend coverage is sufficient, otherwise it falls back to tape close. Candles and technical overlays on /chart stay tape.
Which windows are public?
Public visitors can share 1M, 3M, 6M, YTD, 1Y, and 5Y. MAX is Research+. Direction and regime in the table follow the desk ladder: SPY25 on Free, full book on Essential+.
How do I read the drawdown, period, and annual tables?
Drawdowns are current and worst peak-to-trough on the visible range. Periods are calendar lookbacks (1Y / 2Y / 3Y / 5Y, plus 10Y on MAX) from the last bar. Annual is calendar-year holding return, with the latest year labeled YTD.
How has QURE vs SPY performed on a normalized basis?
QURE vs SPY holding-return overlay: 5Y QURE -29.21% · SPY +86.64%; worst drawdown QURE -89.50% · SPY -24.49%; YTD QURE -9.02% · SPY +14.78%. Numbers update from the live compare-series book.
Is ticker compare investment advice?
No. The overlay is research context only — not a recommendation to buy or sell any security.

Related: QURE, SPY, methodology, chart