Amylyx Pharmaceuticals, Inc. (AMLX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: AMLX +48.59%, SPY +86.64%. Regime AMLX CRISIS · SPY BULL. As of Oct 13, 2026. Research only.
Total return · dividends and splits
AMLX
SPY
| SYMBOL | PRICE | CHANGE | 5Y % | PREV CLOSE | DIR | REGIME |
|---|---|---|---|---|---|---|
| AMLXAmylyx Pharmaceuticals, Inc. | $26.85 | —-2.29% | +48.59% | — | 🔒 | 🔒 |
| SPYState Street SPDR S&P 500 ETF Trust | $778.01 | —-0.01% | +86.64% | — | 🔒 | 🔒 |
DRAWDOWN · THIS RANGE
| SYMBOL | CURRENT | PEAK | WORST | TROUGH |
|---|---|---|---|---|
| AMLX | -34.40% | 2023-01-27 | -96.04% | 2024-06-18 |
| SPY | -0.14% | 2026-10-06 | -24.49% | 2022-10-12 |
PERIODS · 5Y BOOK
| SYMBOL | 1Y | 2Y | 3Y | 5Y |
|---|---|---|---|---|
| AMLX | - | - | - | - |
| SPY | - | - | - | - |
ANNUAL · 5Y BOOK
| YEAR | AMLX | SPY |
|---|---|---|
| - | - | - |
Compare FAQ
- What does the AMLX vs SPY overlay show?
- LOPJLB overlays AMLX vs SPY as total return (dividends and splits) from the first adjusted close in the selected 5Y window. Each path starts at 0% so you can read relative holding performance, not raw tape price.
- Is this holding return or tape close?
- Holding return. The series uses split- and dividend-adjusted close (Yahoo-style backward adjustment) when dividend coverage is sufficient, otherwise it falls back to tape close. Candles and technical overlays on /chart stay tape.
- Which windows are public?
- Public visitors can share 1M, 3M, 6M, YTD, 1Y, and 5Y. MAX is Research+. Direction and regime in the table follow the desk ladder: SPY25 on Free, full book on Essential+.
- How do I read the drawdown, period, and annual tables?
- Drawdowns are current and worst peak-to-trough on the visible range. Periods are calendar lookbacks (1Y / 2Y / 3Y / 5Y, plus 10Y on MAX) from the last bar. Annual is calendar-year holding return, with the latest year labeled YTD.
- How has AMLX vs SPY performed on a normalized basis?
- AMLX vs SPY holding-return overlay: 5Y AMLX +48.59% · SPY +86.64%; worst drawdown AMLX -96.04% · SPY -24.49%; YTD AMLX +135.11% · SPY +14.78%. Numbers update from the live compare-series book.
- Is ticker compare investment advice?
- No. The overlay is research context only — not a recommendation to buy or sell any security.
Related: AMLX, SPY, methodology, chart