# XORTX Therapeutics Inc. (XRTX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

XORTX Therapeutics Inc. (XRTX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: XRTX -99.34%, SPY +92.05%. Regime XRTX CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/XRTX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=XRTX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| XRTX | -99.34% | -99.34% | -50.53% |
| SPY | +92.05% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| XRTX | -68.87% | -83.41% | -88.09% | -99.34% |
| SPY | +17.26% | +38.01% | +86.77% | +92.05% |

## Annual

| Year | XRTX | SPY |
|---|---:|---:|
| YTD | -50.53% | +14.86% |
| 2025 | -51.97% | +18.01% |
| 2024 | -48.64% | +25.59% |
| 2023 | -68.70% | +26.73% |
| 2022 | -62.42% | -18.64% |
| 2021 | -57.01% | +9.92% |

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Research context only. Not personalized investment advice.