# Xeris Biopharma Holdings, Inc. (XERS) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Xeris Biopharma Holdings, Inc. (XERS) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: XERS +412.75%, SPY +91.24%. Regime XERS BULL · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/XERS/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=XERS%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| XERS | +412.75% | -64.85% | +42.31% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| XERS | +31.57% | +252.19% | +562.03% | +412.75% |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | XERS | SPY |
|---|---:|---:|
| YTD | +42.31% | +14.79% |
| 2025 | +126.88% | +18.01% |
| 2024 | +49.34% | +25.59% |
| 2023 | +109.82% | +26.73% |
| 2022 | -52.67% | -18.64% |
| 2021 | +43.63% | +9.53% |

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Research context only. Not personalized investment advice.