# UroGen Pharma Ltd. (URGN) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

UroGen Pharma Ltd. (URGN) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: URGN +122.24%, SPY +84.07%. Regime URGN CRISIS · SPY BULL. As of Oct 14, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/URGN/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=URGN%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| URGN | +122.24% | -82.64% | +61.07% |
| SPY | +84.07% | -24.49% | +13.53% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| URGN | +119.70% | +198.37% | +179.88% | +122.24% |
| SPY | +17.47% | +34.75% | +83.03% | +84.07% |

## Annual

| Year | URGN | SPY |
|---|---:|---:|
| YTD | +61.07% | +13.53% |
| 2025 | +118.88% | +18.01% |
| 2024 | -29.98% | +25.59% |
| 2023 | +73.61% | +26.73% |
| 2022 | -8.84% | -18.64% |
| 2021 | -42.22% | +6.59% |

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Research context only. Not personalized investment advice.