# TherapeuticsMD, Inc. (TXMD) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

TherapeuticsMD, Inc. (TXMD) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: TXMD -94.28%, SPY +92.05%. Regime TXMD RECOVERY · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/TXMD/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=TXMD%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| TXMD | -94.28% | -98.16% | +24.85% |
| SPY | +92.05% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| TXMD | +94.34% | +30.38% | -23.13% | -94.28% |
| SPY | +17.26% | +38.01% | +86.77% | +92.05% |

## Annual

| Year | TXMD | SPY |
|---|---:|---:|
| YTD | +24.85% | +14.86% |
| 2025 | +3.82% | +18.01% |
| 2024 | -63.09% | +25.59% |
| 2023 | -64.00% | +26.73% |
| 2022 | -71.33% | -18.64% |
| 2021 | -50.00% | +9.92% |

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Research context only. Not personalized investment advice.