# Tiziana Life Sciences Ltd (TLSA) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Tiziana Life Sciences Ltd (TLSA) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: TLSA -22.07%, SPY +90.43%. Regime TLSA RECOVERY · SPY BULL. As of Oct 8, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/TLSA/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=TLSA%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| TLSA | -22.07% | -74.88% | -29.38% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| TLSA | -50.66% | +20.21% | +57.40% | -22.07% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | TLSA | SPY |
|---|---:|---:|
| YTD | -29.38% | +14.17% |
| 2025 | +118.86% | +18.01% |
| 2024 | +22.14% | +25.59% |
| 2023 | -3.45% | +26.73% |
| 2022 | -44.95% | -18.64% |
| 2021 | -33.79% | +9.65% |

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Research context only. Not personalized investment advice.