# Amplify Weight Loss Drug & Treatment ETF (THNR) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Amplify Weight Loss Drug & Treatment ETF (THNR) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: THNR -1.39%, SPY +80.74%. As of Oct 19, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/THNR/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=THNR%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| THNR | -1.39% | -32.48% | -4.01% |
| SPY | +80.74% | -24.49% | +13.07% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| THNR | +5.01% | -4.58% | — | — |
| SPY | +15.41% | +34.36% | +86.39% | +80.74% |

## Annual

| Year | THNR | SPY |
|---|---:|---:|
| YTD | -4.01% | +13.07% |
| 2025 | +13.28% | +18.01% |
| 2024 | -10.35% | +25.59% |
| 2023 | — | +26.73% |
| 2022 | — | -18.64% |
| 2021 | — | +5.08% |

---

Research context only. Not personalized investment advice.