# Sarepta Therapeutics, Inc. (SRPT) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Sarepta Therapeutics, Inc. (SRPT) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: SRPT -80.01%, SPY +84.62%. Regime SRPT CRISIS · SPY BULL. As of Oct 14, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/SRPT/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=SRPT%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| SRPT | -80.01% | -92.72% | -21.02% |
| SPY | +84.62% | -24.49% | +13.53% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| SRPT | -21.47% | -86.47% | -85.68% | -80.01% |
| SPY | +17.47% | +34.75% | +83.03% | +84.62% |

## Annual

| Year | SRPT | SPY |
|---|---:|---:|
| YTD | -21.02% | +13.53% |
| 2025 | -82.66% | +18.01% |
| 2024 | +26.38% | +25.59% |
| 2023 | -22.76% | +26.73% |
| 2022 | +43.31% | -18.64% |
| 2021 | +6.96% | +6.90% |

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Research context only. Not personalized investment advice.