# Spero Therapeutics, Inc. (SPRO) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Spero Therapeutics, Inc. (SPRO) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: SPRO -93.05%, SPY +91.57%. Regime SPRO RECOVERY · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/SPRO/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=SPRO%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| SPRO | -93.05% | -96.84% | -48.94% |
| SPY | +91.57% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| SPRO | -49.15% | -3.23% | +4.35% | -93.05% |
| SPY | +17.26% | +38.01% | +86.77% | +91.57% |

## Annual

| Year | SPRO | SPY |
|---|---:|---:|
| YTD | -48.94% | +14.86% |
| 2025 | +115.74% | +18.01% |
| 2024 | -32.24% | +25.59% |
| 2023 | -15.52% | +26.73% |
| 2022 | -88.58% | -18.64% |
| 2021 | -7.30% | +9.65% |

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Research context only. Not personalized investment advice.