# Silexion Therapeutics Ltd. (SLXN) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Silexion Therapeutics Ltd. (SLXN) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: SLXN -99.99%, SPY +91.36%. Regime SLXN CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/SLXN/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=SLXN%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| SLXN | -99.99% | -99.99% | -98.86% |
| SPY | +91.36% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| SLXN | -99.46% | -99.95% | — | — |
| SPY | +17.26% | +38.01% | +86.77% | +91.36% |

## Annual

| Year | SLXN | SPY |
|---|---:|---:|
| YTD | -98.86% | +14.86% |
| 2025 | -93.57% | +18.01% |
| 2024 | -88.55% | +25.59% |
| 2023 | — | +26.73% |
| 2022 | — | -18.64% |
| 2021 | — | +9.53% |

---

Research context only. Not personalized investment advice.