# Soleno Therapeutics, Inc. (SLNO) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Soleno Therapeutics, Inc. (SLNO) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: SLNO -16.39%, SPY +90.43%. Regime SLNO BULL · SPY BULL. As of Oct 8, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/SLNO/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=SLNO%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| SLNO | -16.39% | -92.97% | +12.38% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| SLNO | -29.86% | +12.76% | +142.05% | — |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | SLNO | SPY |
|---|---:|---:|
| YTD | +12.38% | +14.17% |
| 2025 | +1.29% | +18.01% |
| 2024 | +18.45% | +25.59% |
| 2023 | +267.58% | +26.73% |
| 2022 | -70.09% | -18.64% |
| 2021 | -51.50% | +9.65% |

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Research context only. Not personalized investment advice.