# Skye Bioscience, Inc. (SKYE) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Skye Bioscience, Inc. (SKYE) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: SKYE -98.89%, SPY +91.36%. Regime SKYE CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/SKYE/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=SKYE%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| SKYE | -98.89% | -99.09% | -75.96% |
| SPY | +91.36% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| SKYE | -87.72% | -94.35% | -92.54% | -98.89% |
| SPY | +17.26% | +38.01% | +86.77% | +91.36% |

## Annual

| Year | SKYE | SPY |
|---|---:|---:|
| YTD | -75.96% | +14.86% |
| 2025 | -73.68% | +18.01% |
| 2024 | +4.04% | +25.59% |
| 2023 | -36.00% | +26.73% |
| 2022 | -70.91% | -18.64% |
| 2021 | -31.58% | +9.53% |

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Research context only. Not personalized investment advice.