# ALPS Medical Breakthroughs ETF (SBIO) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

ALPS Medical Breakthroughs ETF (SBIO) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: SBIO +18.10%, SPY +80.74%. As of Oct 19, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/SBIO/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=SBIO%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| SBIO | +18.10% | -52.49% | +3.89% |
| SPY | +80.74% | -24.49% | +13.07% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| SBIO | +20.46% | +37.47% | +120.70% | +18.10% |
| SPY | +15.41% | +34.36% | +86.39% | +80.74% |

## Annual

| Year | SBIO | SPY |
|---|---:|---:|
| YTD | +3.89% | +13.07% |
| 2025 | +53.68% | +18.01% |
| 2024 | +4.38% | +25.59% |
| 2023 | +11.05% | +26.73% |
| 2022 | -30.19% | -18.64% |
| 2021 | -7.85% | +5.08% |

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Research context only. Not personalized investment advice.