# Sana Biotechnology, Inc. (SANA) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Sana Biotechnology, Inc. (SANA) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: SANA -85.82%, SPY +92.05%. Regime SANA CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/SANA/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=SANA%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| SANA | -85.82% | -94.21% | -33.41% |
| SPY | +92.05% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| SANA | -37.30% | -30.08% | -23.56% | -85.82% |
| SPY | +17.26% | +38.01% | +86.77% | +92.05% |

## Annual

| Year | SANA | SPY |
|---|---:|---:|
| YTD | -33.41% | +14.86% |
| 2025 | +146.67% | +18.01% |
| 2024 | -61.19% | +25.59% |
| 2023 | +9.38% | +26.73% |
| 2022 | -74.65% | -18.64% |
| 2021 | -21.34% | +9.92% |

---

Research context only. Not personalized investment advice.