# Genenta Science S.p.A. (SAEN) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Genenta Science S.p.A. (SAEN) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: SAEN -93.64%, SPY +75.05%. As of Nov 4, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/SAEN/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=SAEN%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| SAEN | -93.64% | -95.11% | -50.35% |
| SPY | +75.05% | -24.49% | +13.12% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| SAEN | -69.57% | -86.79% | -86.04% | — |
| SPY | +14.79% | +37.68% | +82.51% | +75.05% |

## Annual

| Year | SAEN | SPY |
|---|---:|---:|
| YTD | -50.35% | +13.12% |
| 2025 | -67.11% | +18.01% |
| 2024 | -10.31% | +25.59% |
| 2023 | -9.01% | +26.73% |
| 2022 | -50.89% | -18.64% |
| 2021 | -0.36% | +1.73% |

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Research context only. Not personalized investment advice.