# Recursion Pharmaceuticals, Inc. (RXRX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Recursion Pharmaceuticals, Inc. (RXRX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: RXRX -77.91%, SPY +91.36%. Regime RXRX RECOVERY · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/RXRX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=RXRX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| RXRX | -77.91% | -86.29% | +3.81% |
| SPY | +91.36% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| RXRX | -26.23% | -29.11% | -35.50% | -77.91% |
| SPY | +17.26% | +38.01% | +86.77% | +91.36% |

## Annual

| Year | RXRX | SPY |
|---|---:|---:|
| YTD | +3.81% | +14.86% |
| 2025 | -43.27% | +18.01% |
| 2024 | -31.51% | +25.59% |
| 2023 | +30.60% | +26.73% |
| 2022 | -57.24% | -18.64% |
| 2021 | -13.22% | +9.53% |

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Research context only. Not personalized investment advice.