# Repare Therapeutics Inc. (RPTX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Repare Therapeutics Inc. (RPTX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: RPTX -86.76%, SPY +91.24%. Regime RPTX BULL · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/RPTX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=RPTX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| RPTX | -86.76% | -96.80% | +3.11% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| RPTX | +130.43% | -60.68% | -78.37% | — |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | RPTX | SPY |
|---|---:|---:|
| YTD | +3.11% | +14.79% |
| 2025 | +96.97% | +18.01% |
| 2024 | -82.03% | +25.59% |
| 2023 | -46.05% | +26.73% |
| 2022 | -32.77% | -18.64% |
| 2021 | +5.40% | +9.53% |

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Research context only. Not personalized investment advice.