# Rein Therapeutics Inc. (RNTX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Rein Therapeutics Inc. (RNTX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: RNTX -96.19%, SPY +88.08%. Regime RNTX RECOVERY · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/RNTX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=RNTX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| RNTX | -96.19% | -96.59% | -37.21% |
| SPY | +88.08% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| RNTX | -40.54% | -78.14% | -35.66% | -96.19% |
| SPY | +18.62% | +36.24% | +86.06% | +88.08% |

## Annual

| Year | RNTX | SPY |
|---|---:|---:|
| YTD | -37.21% | +14.79% |
| 2025 | -48.44% | +18.01% |
| 2024 | -26.28% | +25.59% |
| 2023 | -4.73% | +26.73% |
| 2022 | -80.11% | -18.64% |
| 2021 | -45.35% | +7.72% |

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Research context only. Not personalized investment advice.