# Atrium Therapeutics, Inc. (RNA) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Atrium Therapeutics, Inc. (RNA) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: RNA -96.12%, SPY +90.43%. Regime RNA CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/RNA/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=RNA%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| RNA | -96.12% | -98.92% | -98.83% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| RNA | -98.35% | -98.16% | -86.34% | -96.12% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | RNA | SPY |
|---|---:|---:|
| YTD | -98.83% | +14.17% |
| 2025 | +131.33% | +18.01% |
| 2024 | +217.47% | +25.59% |
| 2023 | -55.31% | +26.73% |
| 2022 | -6.69% | -18.64% |
| 2021 | +9.89% | +9.65% |

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Research context only. Not personalized investment advice.