# Rallybio Corporation (RLYB) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Rallybio Corporation (RLYB) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: RLYB -85.51%, SPY +88.08%. Regime RLYB BULL · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/RLYB/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=RLYB%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| RLYB | -85.51% | -98.74% | +196.64% |
| SPY | +88.08% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| RLYB | +297.87% | +94.33% | -41.38% | -85.51% |
| SPY | +18.62% | +36.24% | +86.06% | +88.08% |

## Annual

| Year | RLYB | SPY |
|---|---:|---:|
| YTD | +196.64% | +14.79% |
| 2025 | -27.76% | +18.01% |
| 2024 | -60.00% | +25.59% |
| 2023 | -61.39% | +26.73% |
| 2022 | -36.71% | -18.64% |
| 2021 | -34.12% | +7.72% |

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Research context only. Not personalized investment advice.