# Q32 Bio Inc. (QTTB) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Q32 Bio Inc. (QTTB) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: QTTB -92.53%, SPY +91.36%. Regime QTTB CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/QTTB/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=QTTB%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| QTTB | -92.53% | -98.82% | +142.44% |
| SPY | +91.36% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| QTTB | +157.41% | -82.39% | -57.10% | -92.53% |
| SPY | +17.26% | +38.01% | +86.77% | +91.36% |

## Annual

| Year | QTTB | SPY |
|---|---:|---:|
| YTD | +142.44% | +14.86% |
| 2025 | -3.77% | +18.01% |
| 2024 | -68.32% | +25.59% |
| 2023 | -49.35% | +26.73% |
| 2022 | -69.78% | -18.64% |
| 2021 | -41.29% | +9.53% |

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Research context only. Not personalized investment advice.