# Quanterix Corporation (QTRX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Quanterix Corporation (QTRX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: QTRX -93.48%, SPY +91.24%. Regime QTRX CRISIS · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/QTRX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=QTRX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| QTRX | -93.48% | -95.79% | -50.86% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| QTRX | -46.26% | -74.16% | -84.56% | -93.48% |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | QTRX | SPY |
|---|---:|---:|
| YTD | -50.86% | +14.79% |
| 2025 | -40.89% | +18.01% |
| 2024 | -60.85% | +25.59% |
| 2023 | +112.60% | +26.73% |
| 2022 | -67.34% | -18.64% |
| 2021 | -12.45% | +9.53% |

---

Research context only. Not personalized investment advice.