# Protagonist Therapeutics, Inc. (PTGX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Protagonist Therapeutics, Inc. (PTGX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: PTGX +355.60%, SPY +91.24%. Regime PTGX RECOVERY · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/PTGX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=PTGX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| PTGX | +355.60% | -80.97% | +66.18% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| PTGX | +83.00% | +212.58% | +842.62% | +355.60% |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | PTGX | SPY |
|---|---:|---:|
| YTD | +66.18% | +14.79% |
| 2025 | +124.06% | +18.01% |
| 2024 | +64.82% | +25.59% |
| 2023 | +112.71% | +26.73% |
| 2022 | -69.11% | -18.64% |
| 2021 | +7.55% | +9.53% |

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Research context only. Not personalized investment advice.