# Prothena Corporation plc (PRTA) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Prothena Corporation plc (PRTA) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: PRTA -87.60%, SPY +90.43%. Regime PRTA RECOVERY · SPY BULL. As of Oct 8, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/PRTA/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=PRTA%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| PRTA | -87.60% | -94.17% | -6.41% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| PRTA | -16.81% | -48.41% | -81.84% | -87.60% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | PRTA | SPY |
|---|---:|---:|
| YTD | -6.41% | +14.17% |
| 2025 | -30.14% | +18.01% |
| 2024 | -64.06% | +25.59% |
| 2023 | -32.07% | +26.73% |
| 2022 | +22.41% | -18.64% |
| 2021 | -28.83% | +9.65% |

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Research context only. Not personalized investment advice.