# Direxion Daily Pharmaceutical & Medical Bull 3X ETF (PILL) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Direxion Daily Pharmaceutical & Medical Bull 3X ETF (PILL) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: PILL -13.52%, SPY +81.53%. As of Oct 20, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/PILL/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=PILL%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| PILL | -13.52% | -82.00% | +27.49% |
| SPY | +81.53% | -24.49% | +13.45% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| PILL | +76.01% | +62.58% | +179.50% | -13.52% |
| SPY | +15.80% | +34.81% | +89.35% | +81.53% |

## Annual

| Year | PILL | SPY |
|---|---:|---:|
| YTD | +27.49% | +13.45% |
| 2025 | +79.19% | +18.01% |
| 2024 | -7.50% | +25.59% |
| 2023 | -9.86% | +26.73% |
| 2022 | -44.70% | -18.64% |
| 2021 | -12.60% | +5.19% |

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Research context only. Not personalized investment advice.