# Palisade Bio, Inc. (PALI) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Palisade Bio, Inc. (PALI) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: PALI -99.93%, SPY +92.05%. Regime PALI CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/PALI/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=PALI%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| PALI | -99.93% | -99.98% | -38.40% |
| SPY | +92.05% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| PALI | -26.67% | -54.30% | -80.99% | -99.93% |
| SPY | +17.26% | +38.01% | +86.77% | +92.05% |

## Annual

| Year | PALI | SPY |
|---|---:|---:|
| YTD | -38.40% | +14.86% |
| 2025 | +26.34% | +18.01% |
| 2024 | -80.99% | +25.59% |
| 2023 | -84.55% | +26.73% |
| 2022 | -93.11% | -18.64% |
| 2021 | -52.73% | +9.92% |

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Research context only. Not personalized investment advice.