# CollPlant Biotechnologies Ltd (OPHI) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

CollPlant Biotechnologies Ltd (OPHI) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: OPHI -98.30%, SPY +72.62%. As of Nov 13, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/OPHI/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=OPHI%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| OPHI | -98.30% | -98.73% | -75.34% |
| SPY | +72.62% | -24.49% | +11.29% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| OPHI | -81.57% | -91.53% | -93.55% | -98.30% |
| SPY | +13.46% | +29.24% | +77.71% | +72.62% |

## Annual

| Year | OPHI | SPY |
|---|---:|---:|
| YTD | -75.34% | +11.29% |
| 2025 | -63.25% | +18.01% |
| 2024 | -40.50% | +25.59% |
| 2023 | -25.70% | +26.73% |
| 2022 | -49.09% | -18.64% |
| 2021 | -23.66% | +1.97% |

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Research context only. Not personalized investment advice.