# Omeros Corporation (OMER) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Omeros Corporation (OMER) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: OMER +165.99%, SPY +91.24%. Regime OMER RECOVERY · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/OMER/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=OMER%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| OMER | +165.99% | -86.97% | +19.84% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| OMER | +368.50% | +394.46% | +719.62% | +165.99% |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | OMER | SPY |
|---|---:|---:|
| YTD | +19.84% | +14.79% |
| 2025 | +74.59% | +18.01% |
| 2024 | +200.30% | +25.59% |
| 2023 | +31.85% | +26.73% |
| 2022 | -67.67% | -18.64% |
| 2021 | -12.87% | +9.53% |

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Research context only. Not personalized investment advice.