# Neurogene Inc. (NGNE) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Neurogene Inc. (NGNE) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: NGNE -81.28%, SPY +92.05%. Regime NGNE CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/NGNE/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=NGNE%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| NGNE | -81.28% | -95.26% | +30.95% |
| SPY | +92.05% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| NGNE | -16.35% | -46.72% | +64.18% | -81.28% |
| SPY | +17.26% | +38.01% | +86.77% | +92.05% |

## Annual

| Year | NGNE | SPY |
|---|---:|---:|
| YTD | +30.95% | +14.86% |
| 2025 | -10.00% | +18.01% |
| 2024 | +15.05% | +25.59% |
| 2023 | +91.88% | +26.73% |
| 2022 | -90.27% | -18.64% |
| 2021 | -31.63% | +9.92% |

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Research context only. Not personalized investment advice.