# NeoGenomics, Inc. (NEO) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

NeoGenomics, Inc. (NEO) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: NEO -60.99%, SPY +90.43%. Regime NEO CRISIS · SPY BULL. As of Oct 8, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/NEO/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=NEO%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| NEO | -60.99% | -89.72% | +36.22% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| NEO | +74.70% | +19.20% | +33.95% | -60.99% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | NEO | SPY |
|---|---:|---:|
| YTD | +36.22% | +14.17% |
| 2025 | -28.68% | +18.01% |
| 2024 | +3.32% | +25.59% |
| 2023 | +78.00% | +26.73% |
| 2022 | -73.81% | -18.64% |
| 2021 | -16.92% | +9.65% |

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Research context only. Not personalized investment advice.