# Monopar Therapeutics Inc. (MNPR) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Monopar Therapeutics Inc. (MNPR) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: MNPR +238.88%, SPY +91.57%. Regime MNPR CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/MNPR/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=MNPR%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| MNPR | +238.88% | -94.47% | +19.62% |
| SPY | +91.57% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| MNPR | -21.79% | +1454.33% | +2792.31% | +238.88% |
| SPY | +17.26% | +38.01% | +86.77% | +91.57% |

## Annual

| Year | MNPR | SPY |
|---|---:|---:|
| YTD | +19.62% | +14.86% |
| 2025 | +193.88% | +18.01% |
| 2024 | +1089.19% | +25.59% |
| 2023 | -85.34% | +26.73% |
| 2022 | -30.29% | -18.64% |
| 2021 | -31.12% | +9.65% |

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Research context only. Not personalized investment advice.