# Milestone Scientific Inc. (MLSS) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Milestone Scientific Inc. (MLSS) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: MLSS -84.44%, SPY +91.57%. Regime MLSS CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/MLSS/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=MLSS%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| MLSS | -84.44% | -90.91% | +18.76% |
| SPY | +91.57% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| MLSS | -34.82% | -59.54% | -61.96% | -84.44% |
| SPY | +17.26% | +38.01% | +86.77% | +91.57% |

## Annual

| Year | MLSS | SPY |
|---|---:|---:|
| YTD | +18.76% | +14.86% |
| 2025 | -70.96% | +18.01% |
| 2024 | +45.45% | +25.59% |
| 2023 | +41.95% | +26.73% |
| 2022 | -77.88% | -18.64% |
| 2021 | -8.44% | +9.65% |

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Research context only. Not personalized investment advice.