# LAVA Therapeutics N.V. (LVTX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

LAVA Therapeutics N.V. (LVTX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: LVTX -76.92%, SPY +91.24%. Regime LVTX BULL · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/LVTX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=LVTX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| LVTX | -76.92% | -88.33% | +68.93% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| LVTX | +8.75% | +15.23% | -70.46% | — |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | LVTX | SPY |
|---|---:|---:|
| YTD | — | +14.79% |
| 2025 | +68.93% | +18.01% |
| 2024 | -45.66% | +25.59% |
| 2023 | -56.11% | +26.73% |
| 2022 | -41.76% | -18.64% |
| 2021 | -27.06% | +9.53% |

---

Research context only. Not personalized investment advice.