# Eli Lilly and Company (LLY) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Eli Lilly and Company (LLY) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: LLY +431.96%, SPY +85.53%. Regime LLY BEAR · SPY BULL. As of Sep 23, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/LLY/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=LLY%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| LLY | +431.96% | -34.47% | +7.06% |
| SPY | +85.53% | -24.49% | +13.27% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| LLY | +55.06% | +27.07% | +112.74% | +431.96% |
| SPY | +17.02% | +37.89% | +84.21% | +85.53% |

## Annual

| Year | LLY | SPY |
|---|---:|---:|
| YTD | +7.06% | +13.27% |
| 2025 | +39.14% | +18.01% |
| 2024 | +31.21% | +25.59% |
| 2023 | +61.28% | +26.73% |
| 2022 | +36.46% | -18.64% |
| 2021 | +22.41% | +7.68% |

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Research context only. Not personalized investment advice.