# Disc Medicine, Inc. (IRON) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Disc Medicine, Inc. (IRON) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: IRON +49.84%, SPY +84.62%. Regime IRON CRISIS · SPY BULL. As of Oct 14, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/IRON/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=IRON%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| IRON | +49.84% | -68.88% | -29.52% |
| SPY | +84.62% | -24.49% | +13.53% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| IRON | -23.64% | +16.15% | +18.70% | +49.84% |
| SPY | +17.47% | +34.75% | +83.03% | +84.62% |

## Annual

| Year | IRON | SPY |
|---|---:|---:|
| YTD | -29.52% | +13.53% |
| 2025 | +27.16% | +18.01% |
| 2024 | +6.14% | +25.59% |
| 2023 | +221.78% | +26.73% |
| 2022 | -35.42% | -18.64% |
| 2021 | -21.77% | +6.90% |

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Research context only. Not personalized investment advice.