# IO Biotech, Inc. (IOBT) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

IO Biotech, Inc. (IOBT) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: IOBT -99.97%, SPY +91.57%. Regime IOBT CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/IOBT/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=IOBT%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| IOBT | -99.97% | -99.97% | -99.40% |
| SPY | +91.57% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| IOBT | -99.59% | -99.74% | -99.80% | — |
| SPY | +17.26% | +38.01% | +86.77% | +91.57% |

## Annual

| Year | IOBT | SPY |
|---|---:|---:|
| YTD | -99.40% | +14.86% |
| 2025 | -34.23% | +18.01% |
| 2024 | -51.83% | +25.59% |
| 2023 | -21.99% | +26.73% |
| 2022 | -67.74% | -18.64% |
| 2021 | -59.11% | +9.65% |

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Research context only. Not personalized investment advice.