# Insmed Incorporated (INSM) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Insmed Incorporated (INSM) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: INSM +241.87%, SPY +91.24%. Regime INSM CRISIS · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/INSM/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=INSM%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| INSM | +241.87% | -56.54% | -44.35% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| INSM | -39.88% | +31.27% | +302.94% | +241.87% |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | INSM | SPY |
|---|---:|---:|
| YTD | -44.35% | +14.79% |
| 2025 | +148.81% | +18.01% |
| 2024 | +130.59% | +25.59% |
| 2023 | +61.57% | +26.73% |
| 2022 | -28.97% | -18.64% |
| 2021 | -5.52% | +9.53% |

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Research context only. Not personalized investment advice.