# Inovio Pharmaceuticals, Inc. (INO) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Inovio Pharmaceuticals, Inc. (INO) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: INO -98.66%, SPY +90.43%. Regime INO CRISIS · SPY BULL. As of Oct 8, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/INO/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=INO%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| INO | -98.66% | -99.27% | -35.50% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| INO | -57.42% | -80.84% | -74.77% | -98.66% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | INO | SPY |
|---|---:|---:|
| YTD | -35.50% | +14.17% |
| 2025 | -4.40% | +18.01% |
| 2024 | -72.97% | +25.59% |
| 2023 | -66.45% | +26.73% |
| 2022 | -70.00% | -18.64% |
| 2021 | -26.62% | +9.65% |

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Research context only. Not personalized investment advice.