# Inhibikase Therapeutics, Inc. (IKT) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Inhibikase Therapeutics, Inc. (IKT) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: IKT -83.94%, SPY +91.24%. Regime IKT CRISIS · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/IKT/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=IKT%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| IKT | -83.94% | -93.78% | -5.13% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| IKT | +13.50% | +16.35% | +100.69% | -83.94% |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | IKT | SPY |
|---|---:|---:|
| YTD | -5.13% | +14.79% |
| 2025 | -37.69% | +18.01% |
| 2024 | +144.36% | +25.59% |
| 2023 | -60.92% | +26.73% |
| 2022 | -69.70% | -18.64% |
| 2021 | -23.44% | +9.53% |

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Research context only. Not personalized investment advice.