# iShares Genomics Immunology and Healthcare ETF (IDNA) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

iShares Genomics Immunology and Healthcare ETF (IDNA) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: IDNA -13.56%, SPY +80.74%. As of Oct 19, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/IDNA/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=IDNA%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| IDNA | -13.56% | -65.71% | +56.87% |
| SPY | +80.74% | -24.49% | +13.07% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| IDNA | +63.81% | +72.92% | +135.45% | -13.56% |
| SPY | +15.41% | +34.36% | +86.39% | +80.74% |

## Annual

| Year | IDNA | SPY |
|---|---:|---:|
| YTD | +56.87% | +13.07% |
| 2025 | +16.61% | +18.01% |
| 2024 | -2.33% | +25.59% |
| 2023 | -7.24% | +26.73% |
| 2022 | -42.36% | -18.64% |
| 2021 | -11.39% | +5.08% |

---

Research context only. Not personalized investment advice.