# iShares Neuroscience and Healthcare ETF (IBRN) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

- Interactive: https://www.lopjlb.com/vs/IBRN/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=IBRN%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| IBRN | +58.98% | -35.36% | +21.11% |
| SPY | +84.06% | -24.49% | +12.72% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| IBRN | +50.73% | +60.53% | +73.17% | — |
| SPY | +19.36% | +43.50% | +78.48% | +84.06% |

## Annual

| Year | IBRN | SPY |
|---|---:|---:|
| YTD | +21.11% | +12.72% |
| 2025 | +26.05% | +18.01% |
| 2024 | -1.59% | +25.59% |
| 2023 | +2.84% | +26.73% |
| 2022 | +5.82% | -18.64% |
| 2021 | — | +7.35% |

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Research context only. Not personalized investment advice.