# Tema Cardiovascular and Metabolic ETF (HRTS) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Tema Cardiovascular and Metabolic ETF (HRTS) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: HRTS +41.65%, SPY +90.82%. Regime HRTS BEAR · SPY BULL. As of Sep 28, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/HRTS/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=HRTS%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| HRTS | +41.65% | -25.79% | +3.65% |
| SPY | +90.82% | -24.49% | +12.95% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| HRTS | +22.91% | +12.26% | — | — |
| SPY | +16.60% | +36.52% | +85.27% | +90.82% |

## Annual

| Year | HRTS | SPY |
|---|---:|---:|
| YTD | +3.65% | +12.95% |
| 2025 | +22.61% | +18.01% |
| 2024 | -4.41% | +25.59% |
| 2023 | +14.95% | +26.73% |
| 2022 | — | -18.64% |
| 2021 | — | +11.07% |

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Research context only. Not personalized investment advice.