# Harmony Biosciences Holdings, Inc. (HRMY) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Harmony Biosciences Holdings, Inc. (HRMY) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: HRMY +2.80%, SPY +91.24%. Regime HRMY BEAR · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/HRMY/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=HRMY%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| HRMY | +2.80% | -68.48% | +2.27% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| HRMY | +45.03% | +7.75% | +26.32% | +2.80% |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | HRMY | SPY |
|---|---:|---:|
| YTD | +2.27% | +14.79% |
| 2025 | +7.44% | +18.01% |
| 2024 | +11.76% | +25.59% |
| 2023 | -39.01% | +26.73% |
| 2022 | +23.02% | -18.64% |
| 2021 | +14.65% | +9.53% |

---

Research context only. Not personalized investment advice.