# Global X - Genomics & Biotechnology ETF (GNOM) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Global X - Genomics & Biotechnology ETF (GNOM) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: GNOM -19.53%, SPY +89.86%. Regime GNOM BULL · SPY BULL. As of Oct 7, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/GNOM/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=GNOM%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| GNOM | -19.53% | -68.90% | +46.52% |
| SPY | +89.86% | -24.49% | +14.66% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| GNOM | +66.13% | +55.94% | +71.72% | -19.53% |
| SPY | +17.41% | +40.04% | +86.44% | +89.86% |

## Annual

| Year | GNOM | SPY |
|---|---:|---:|
| YTD | +46.52% | +14.66% |
| 2025 | +17.49% | +18.01% |
| 2024 | -16.87% | +25.59% |
| 2023 | -7.67% | +26.73% |
| 2022 | -36.69% | -18.64% |
| 2021 | -5.85% | +8.86% |

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Research context only. Not personalized investment advice.