# Enanta Pharmaceuticals, Inc. (ENTA) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Enanta Pharmaceuticals, Inc. (ENTA) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: ENTA -83.83%, SPY +88.06%. Regime ENTA CRISIS · SPY BULL. As of Oct 13, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/ENTA/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=ENTA%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| ENTA | -83.83% | -95.62% | -20.11% |
| SPY | +88.06% | -24.49% | +14.78% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| ENTA | +0.26% | +1.86% | +19.63% | -83.83% |
| SPY | +18.61% | +36.22% | +86.97% | +88.06% |

## Annual

| Year | ENTA | SPY |
|---|---:|---:|
| YTD | -20.11% | +14.78% |
| 2025 | +182.11% | +18.01% |
| 2024 | -42.96% | +25.59% |
| 2023 | -79.43% | +26.73% |
| 2022 | -37.23% | -18.64% |
| 2021 | +4.95% | +7.72% |

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Research context only. Not personalized investment advice.