# Bright Minds Biosciences Inc. (DRUG) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Bright Minds Biosciences Inc. (DRUG) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: DRUG +32.65%, SPY +90.43%. Regime DRUG CRISIS · SPY BULL. As of Oct 8, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/DRUG/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=DRUG%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| DRUG | +32.65% | -97.67% | -37.69% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| DRUG | -5.80% | +4714.81% | +3437.41% | +32.65% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | DRUG | SPY |
|---|---:|---:|
| YTD | -37.69% | +14.17% |
| 2025 | +89.83% | +18.01% |
| 2024 | +1857.61% | +25.59% |
| 2023 | -63.33% | +26.73% |
| 2022 | -78.04% | -18.64% |
| 2021 | -59.57% | +9.65% |

---

Research context only. Not personalized investment advice.