# Definium Therapeutics, Inc. (DFTX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Definium Therapeutics, Inc. (DFTX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: DFTX +11.31%, SPY +90.43%. Regime DFTX BEAR · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/DFTX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=DFTX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| DFTX | +11.31% | -95.01% | +170.53% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| DFTX | +195.20% | +602.86% | +1142.42% | +11.31% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | DFTX | SPY |
|---|---:|---:|
| YTD | +170.53% | +14.17% |
| 2025 | +77.59% | +18.01% |
| 2024 | +92.27% | +25.59% |
| 2023 | +46.99% | +26.73% |
| 2022 | -90.35% | -18.64% |
| 2021 | -37.56% | +9.65% |

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Research context only. Not personalized investment advice.