# Crinetics Pharmaceuticals, Inc. (CRNX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Crinetics Pharmaceuticals, Inc. (CRNX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: CRNX +333.64%, SPY +91.36%. Regime CRNX BULL · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/CRNX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=CRNX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| CRNX | +333.64% | -57.88% | +81.79% |
| SPY | +91.36% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| CRNX | +155.11% | +63.30% | +406.26% | — |
| SPY | +17.26% | +38.01% | +86.77% | +91.36% |

## Annual

| Year | CRNX | SPY |
|---|---:|---:|
| YTD | +81.79% | +14.86% |
| 2025 | -9.70% | +18.01% |
| 2024 | +44.48% | +25.59% |
| 2023 | +96.57% | +26.73% |
| 2022 | -35.36% | -18.64% |
| 2021 | +45.02% | +9.53% |

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Research context only. Not personalized investment advice.