# Catalyst Pharmaceuticals, Inc. (CPRX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Catalyst Pharmaceuticals, Inc. (CPRX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: CPRX +401.43%, SPY +92.05%. Regime CPRX BULL · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/CPRX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=CPRX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| CPRX | +401.43% | -45.37% | +36.03% |
| SPY | +92.05% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| CPRX | +49.88% | +85.24% | +130.53% | — |
| SPY | +17.26% | +38.01% | +86.77% | +92.05% |

## Annual

| Year | CPRX | SPY |
|---|---:|---:|
| YTD | +36.03% | +14.86% |
| 2025 | +8.46% | +18.01% |
| 2024 | +21.98% | +25.59% |
| 2023 | -6.92% | +26.73% |
| 2022 | +168.79% | -18.64% |
| 2021 | +7.80% | +9.92% |

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Research context only. Not personalized investment advice.